Diplopia in Parkinson's disease: Indication of a cortical phenotype with cognitive dysfunction?

BACKGROUND Visual disturbances are increasingly recognized as common non-motor symptoms in Parkinson's disease (PD). In PD patients, intermittent diplopia has been found to be associated with the presence of visual hallucinations and psychosis spectrum. Here, we investigated whether is other traits cognitive impairment. METHODS We 50 non-demented patients without 24 healthy controls for disturbances, well motor symptoms. All participants underwent a neuropsychological test battery; visuospatial abilities were further evaluated subtests Object Space Perception Battery (VOSP). The two patient groups did not differ significantly age, symptom duration, severity, frequency hallucinations, or sensory efficiency. RESULTS reported more frequent including subjective problems apathy changes global cognition measures compared those diplopia. had greater impairment several tests function (pentagon copying p = .002; number location p = .001; cube analysis p < .02) object perception (p < .001) controls. By contrast, no consistent group differences observed executive function, memory, language. CONCLUSIONS have burden deficits might prone cortical phenotype decline worse prognosis.